What is THIOLAN?

THIOLAN is an injectable preparation of glutathione

Active substance: glutathione

Glutathione is a tripeptide with a specific function, widely distributed in cells. The composition of glutathione includes glycine, cysteine ​​and glutamic acid. Glutathione is a strong hepatoprotector, antioxidant, immunostimulant and detoxicant. Glutathione binding to heavy metal ions, which act on sulfhydryl and disulfide groups of proteins, detoxifies them. Glutathione is involved in the metabolism, as a carrier of hydrogen. It has antioxidant properties. Glutathione is a powerful neuroprotective agent. The use of glutathione promotes the restoration of neuronal interactions and protects the nerve tissue from harmful effects. Erythrocytes containing reduced glutathione in a small amount are relatively easily destroyed. Glutathione protects the pancreas from oxidative damage, has an effect on lipid metabolism, prevents the formation of atherosclerosis, slows down the aging process. Glutathione reduces some of the negative effects associated with reperfusion in acute myocardial infarction. Deficiency of glutathione reflected on the nervous system, leads to violations of thought processes, coordination and is the cause of tremors

  • THIOLAN has a pronounced neuroprotective effect
  • THIOLAN normalizes metabolic processes, stabilizes the central nervous system
  • THIOLAN reduces the manifestations of liver failure, promotes the elimination of toxins
  • As an accompanying therapy in the course of chemotherapy and radiation therapy in cancer patients, in order to protect against toxic effects on the nervous system
  • With cachexia of cancer patients
  • Toxic liver damage
  • Diabetes
  • In the postoperative period
  • Acute myocardial infarction
  • Encephalopathy
  • Craniocerebral trauma
  • Poisoning of various etiologies

Oncology: THIOLAN is used to protect the ionizing effect in radio and radiation therapy - 1200 mg intravenously slowly in physiological saline 15 minutes before radiotherapy. In order to protect neurons, cardiac cells, nephrons from toxicity of chemotherapy (cisplatin, oxaliplatin, cyclophosphomid, 5 FU, etc.), THIOLAN is prescribed in dosage: 1200 mg - 2400 mg slowly intravenously (50-200 ml of water for injection or physiological solution ) 15 minutes before the use of chemotherapy. Further, 600 mg to 1200 mg of GSH are taken from 2 to 5 days. Repeat the injection of Thiolan every week for 1200 mg intravenously
With cachexia in cancer patients: 600 mg/day. Intravenously slow
Liver disorders: toxic, including alcoholic, viral, medicinal (antibiotics, antitumor, antituberculosis, antiviral drugs, antidepressants, oral contraceptives) 1200 mg / day intravenously until recovery
To protect hepatocytes in viral hepatitis: suppresses the replication of HAV, HBV, HCV, and also enhances the effect of antiviral therapy with interferons - 600 mg/day
Cirrhosis of the liver, precirculatory conditions, intrahepatic cholestasis: 600 mg/day
For the regression of alflatoxin-induced liver cancer: the dosage is 1200 mg/day intravenously
Diabetes mellitus, for increasing glucose tolerance, thyrotoxicosis to prevent secondary complications in patients with diabetes mellitus (hypertension, vascular lesions, neuropathy, decreased platelet aggregation) - 600 mg/day intravenously continuously for several weeks and then 2-3 times a week for a long time
Postoperative period: (to eliminate residual anesthesia phenomena) - 600-1200 mg/day intravenously
Acute myocardial infarction: to eliminate side effects associated with reperfusion. Dosage: 1200-1800 mg/day intravenously
Encephalopathy, including, associated with hepatic insufficiency (alcoholic, etc.): 1200 mg per day for 10-15 days, then weekly 600 mg for a long time
Atherosclerosis, depressive and withdrawal symptoms, psychological trauma: 600 mg weekly
Parkinsonism, Alzheimer's disease: 600 mg/day for one to two months, then weekly for a long time
Craniocerebral trauma: up to 1800 mg per day in the acute period, 600-1200 mg until the state stabilizes
Poisonings of various etiologies: (alcohol, drugs, heavy metals, etc.) - 1200 mg in the acute period and 600 mg per day until complete recovery
In sports medicine: weekly 600-1200 mg. Route of administration: for mild forms, the drug is administered intramuscularly, intravenously, slowly (2-3 minutes) or by infusion. To obtain appropriate explanations for the use of the drug, patients are advised to consult a doctor

In rare cases, nausea, vomiting, headache, and skin rash occur after the drug is discontinued. The study of instructions contained in the reference sheet reduces the risk of adverse reactions. It is necessary to inform the doctor about any side reaction, even if it is not described in the instructions

Avoid using in case of known hypersensitivity to one or more components of the product. Children under 12 years. Pregnancy and lactation

With intramuscular application, the preparation must be thoroughly dissolved in an ampoule of the solvent. The resulting solution should be clear and colorless. When used intravenously, the drug must be dissolved in the attached solvent and injected slowly or add at least 20 ml of a sterile solution for infusion and injected slowly by drop

Store in a dark place at a temperature not above 25 °C. Keep out of the reach of children! After dilution, the solution can be stored for 2 hours at room temperature or 8 hours at 0 °C + 5 °C

Ampoules: 10 with powder for inj. (1 ampoule - 600 mg) and 10 ampules with a solvent

By prescription